Anti-UAT (Urate transporter/channel) responses

Anti-UAT (Urate transporter/channel) is a polymer compound, nucleic acerbic by abundant nucleotide. Each nucleotide consists of three parts, a phosphate molecule, a pentose sugar, and a abject (a purine or pyrimidine). Biological basis of the abiogenetic actual DNA (deoxyribonucleic acid) and RNA (ribonucleic acid), the cytoplasm by the hundreds of thousands, millions or even tens of millions of nucleotides. In turn, if the artefact is one of the purine nucleic acerbic oxidative decomposition, so that the purine is an basic basic of the cell. The old beef of the body, as able-bodied as food, abnormally of purine-rich foods (such as agency meats, seafood, etc.) in the metabolic processes in the body, the nucleic acerbic blaze atomization articles there purines (the autogenous purine absolute purine 80%). Again in the liver, the physique produces purine blaze (2,6,8 - three oxygen purine), aswell accepted as uric acid. 2/3 of uric acerbic by the kidneys excreted in the urine, 1/3 through the carrion and diaphoresis discharge. Visible, purine metabolites of nucleic acerbic oxidative decomposition, and Uric acerbic is the final artefact of purine metabolism, wherein the purine ring is not solved. Top levels of uric acerbic is proportional to the purine agreeable in food. Aliment assimilation of 50% of the RNA, DNA, 25% have to be in the anatomy of uric acerbic in urine excretion, serum uric acerbic levels can carefully absolute the assimilation of purine to 60umol / L (1 0mg/dL), while beard of uric acerbic in the urine alone to 1.2 mmol / d (200 mg / d). Purine metabolism of endogenous, exogenous factors are added important. The de novo amalgam of purine by the non-cyclic ring to go through a 11-step reaction, wherein the agitator will advance to an almighty ample amount of purine amalgam excessive. Has now been found: phosphoribosyl pyrophosphate (PRPP) synthetase action increases. Hypoxanthine - guanine phosphoribosyl-converting agitator (HGPRT) deficiency. Abridgement of glucose 6 - phosphatase (glucose-6-phosphatase).

Under accustomed circumstances, the physique of Anti-UAT (Urate transporter/channel) is about 1200 mg, the new bearing of about 600 mg per day, at the aforementioned time was excreted to 600 mg, in a counterbalanced state. But if the physique produces too abundant time to elimination or abasement of the uric acerbic elimination mechanisms, uric acerbic assimilation too abundant will advance to gout, claret uric acerbic concentrations greater than 7 mg / L, could cause physique fluids sour, affect the accustomed action of animal cells, abiding abandoned . In addition, too abundant fatigue or abridgement of blow can advance to almost apathetic metabolism advance to the access of gout. All claret uric acerbic from the glomerular filtration, 98% of in adjacent tubule average and is buried into the glomerular cavity, again 50% of the reabsorption of uric acerbic in the adjacent tubule average buried into the tubular atrium beeline area in the adjacent tubule, there are 40% to 44% reabsorption, alone 6% to 10% of the elimination of uric acid. The accustomed animal physique uric acerbic elimination amount is almost constant. Levels of uric acerbic in the physique fluids, can absolutely reflect the animal physique metabolism, allowed function. According to the apparatus of uric acerbic production, we in about-face derive: To anticipate gout is all-important to abate the assembly of uric acid, to abate the assembly of uric acerbic is all-important to abate the purines in the body, abate the physique the purine is all-important to abate the nucleic acerbic blaze and decomposition, and purine camera into, while deepening the exclusion of uric acid. Diet is the capital antecedent of exogenous purine and uric acerbic in patients with uric acerbic from the diet nucleotide atomization from top uric acerbic (gout). About 20% of the absolute physique of uric acid. On hyperuricemia, the autogenous metabolic disorders is added important than the exogenous factors. If top claret uric acid, purine, gout to anatomy a alternation of reactions. Therefore had top uric acerbic (gout) can not eat and what to eat is actual important, patients have to be in the top uric acerbic (gout) treatment, have to pay absorption to top uric acerbic (gout) diet.

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