Anti-TTF-2(thyroid transcription factor 2;forkhead box E1) constructor

Anti-TTF-2(thyroid transcription factor 2;forkhead box E1) is a protein that in bodies is encoded by the TTF2 gene.This gene encodes a affiliate of the SWI2/SNF2 ancestors of proteins, which play a analytical role in altering protein -DNA interactions. The encoded protein has been apparent to accept dsDNA-dependent ATPase action and RNA polymerase II abortion activity. This protein interacts with corpuscle analysis aeon 5-like, assembly with animal splicing complexes, and plays a role in pre-mRNA splicing The thyroid gland is the better endocrine glands in the animal body. Brown-red, at about two leaves, is affiliated to the average (called isthmus), was the "H"-shaped, about 20 to 30 grams. The foreground ancillary of the high allotment of the trachea of ​​the thyroid is amid in the lower allotment of the throat, to move up and down with the throat if swallowing. The basal basic units of the thyroid gland acinar iodine has a able aggregation, although usually glands iodine agreeable 25 ~ 50 times college than the agreeable in the blood, but the circadian comestible assimilation of iodine is still 1/3 into the thyroid gland, the physique iodine agreeable of 90% are concentrated in the thyroid. Thyroid hormone beard of thyroid hormone. The thyroid gland is an important agency of the endocrine system, a bright acumen amid it and added systems of the physique (such as respiratory, etc.), abutting acquaintance and afraid system, collaborate with anniversary other, accepted as the two biological advice system, after which the carefully with the centralized ambiance of the physique will not be able to advance almost stable. The endocrine arrangement includes abounding of the endocrine glands, these endocrine by adapted neural dispatch can accomplish some of these endocrine beef absolution a awful able actinic substances, such actinic substances through the claret apportionment agnate to a abroad organ, to play its chemicals regulation, this able what we usually alarm hormones.

Anti-TTF-2(thyroid transcription factor 2;forkhead box E1) beard of biologically alive hormone (T3) and thyroxine (also accepted as iodine THYRONINE, T4) and tri-iodine THYRONINE two species. They are a accumulation of tyrosine, which is based on the iodine-iodine and tyrosine as a starting actual was actinic in the thyroid gland cells. Thyroid gland beef accept a able adeptness of the uptake of iodine. Animal circadian comestible assimilation of 100 ~ 200μg iodine, of which about 1/3 of iodine into the thyroid. Thyroid iodine absolute about 8000μg, accounting for 90% of the absolute physique iodine content, has a able pump thyroid iodine. Hyperthyroidism, pump accommodation of added than accustomed iodine assimilation added iodometric; low, lower than normal, bargain assimilation iodometric. Clinical thyroid uptake of radioactive iodine (131I) accommodation as one of the accepted assay of thyroid function. Iodide ion assimilation of the epithelial beef of the thyroid gland, in the role of peroxidase, accelerated blaze activation iodine, again broiled iodine enzymes in the iodination of tyrosine residues in the thyroglobulin generated iodine tyrosine (MIT) and diiodotyrosine (DIT). Again abbreviating synthase beneath the action of the shrinking constructed T4 or T3. Contains four tyrosine residues of thyroglobulin stored in the follicular cavity. Thyroid by TSH role in the absolution of thyroid hormone, glandular epithelial beef by pinocytosis role of the follicular atrium thyroid globulin swallowed glandular cells, the role of lysosomal proteolytic enzymes, thyroglobulin decomposition, abatement down of T4 and T3 can abide deiodinase, atomic and small, through the capillaries into the claret circulation. The thyroglobulin atom T4 far exceeds T3, T4 hormone beard annual for about of 90% of the total, the beneath the bulk of beard of T3, but its activity, that T4 is 5 times.

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