Functions of GFAP (phospho-Ser8) Monoclonal Antibody (YC10)

Glial fibrillary acidic protein (GFAP) is a protein that in bodies is encoded by the GFAP gene.
Glial fibrillary acerb protein is an average fiber (IF) protein that is bidding by abundant corpuscle types of the axial afraid arrangement (CNS) including astrocytes, and ependymal cells. GFAP has aswell been begin to be bidding in glomeruli and peritubular fibroblasts taken from rat kidneys Leydig beef of the testis in both hamsters and humans, animal keratinocytes, animal osteocytes and chondrocytes and stellate beef of the pancreas and alarmist in rats. First declared in 1971, GFAP is a blazon III IF protein that maps, in humans, to 17q21. It is carefully accompanying to its non-epithelial ancestors members, vimentin, desmin, and peripherin, which are all complex in the anatomy and action of the cell’s cytoskeleton. GFAP is anticipation to advice to advance astrocyte automated strength, as able-bodied as the appearance of beef but its exact action charcoal ailing understood, admitting the bulk of studies application it as a corpuscle marker.
Function in the axial afraid system
GFAP is bidding in the axial afraid arrangement in astrocyte cells. It is complex in abounding important CNS processes, including corpuscle advice and the activity of the claret academician barrier.
GFAP has been apparent to play a role in mitosis by adjusting the fiber arrangement present in the cell. During mitosis, there is an access in the bulk of phosphorylated GFAP, and a movement of this adapted protein to the break furrow. There are altered sets of kinases at work; cdc2 kinase acts abandoned at the G2 appearance transition, while added GFAP kinases are alive at the break channel alone. This specificity of area allows for absolute adjustment of GFAP administration to the babe cells. Studies accept aswell apparent that GFAP knockout mice abide assorted degenerative processes including aberrant myelination, white amount anatomy deterioration, and functional/structural crime of the blood-brain barrier. These abstracts advance that GFAP is all-important for abounding analytical roles in the CNS.
GFAP is proposed to play a role in astrocyte-neuron interactions as able-bodied as cell-cell communication. In vitro, application antisense RNA, astrocytes defective GFAP do not anatomy the extensions usually present with neurons. Studies accept aswell apparent that Purkinje beef in GFAP knockout mice do not display accustomed structure, and these mice authenticate deficits in conditioning abstracts such as the eye-blink task. Biochemical studies of GFAP accept apparent MgCl2 and/or calcium/calmodulin abased phosphorylation at assorted serine or threonine residues by PKC and PKA which are two kinases that are important for the cytoplasmic transduction of signals. These abstracts highlight the accent of GFAP for cell-cell communication.
GFAP has aswell been apparent to be important in adjustment afterwards CNS injury. More accurately for its role in the accumulation of glial scars in a aggregation of locations throughout the CNS including the eye and brain.
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