What is Cdk1 (cdc2) (phospho-Tyr15) Polyclonal Antibody?

Cdk1/cdc2 is a Ser/Thr kinase that serves as the catalytic subunit of the M-phase Promoting Factor (MPF) complex. MPF is critical for appropriate regulation of cell cycle progression, specifically for control of the G1/S and G2/M phase transition. Cdc2 activity is controlled by the presence of Cyclins, which appear and are then degraded at specific times during the cell cycle in a tightly regulated manner. cdc2 activity is also regulated by phosphorylation.
CDC2, phosphoTyr15. By Western blot the antibody recognizes the ~35 kDa phospho CDC2 protein. The labeling of the CDC2 band in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
More about: Cdk1 (cdc2) (phospho-Tyr15) Polyclonal Antibody sale
Read more: phospho antibody