PDZK1 is a protein that consists of 4 bike PDZ domains. As such it is a arch protein that connects claret film proteins and authoritative components, acclimation their apparent announcement in epithelial beef aciculate domains. It has been proposed to be complex in the allocation of a assorted ambit of authoritative processes for ion carriage and additional agent cascades like adjustment of adjacent tubular Na(+)-dependent asleep phosphate or cellular mechanisms associated with multidrug attrition through its alternation with ABCC2 and PDZK1IP1. PDZK1 has aswell been proposed to potentiate CFTR chloride approach action and action to affix SCARB1 with the cellular machineries for intracellular cholesterol carriage and/or metabolism. It plays a physiologically role in both oligopeptide administration as able-bodied as peptide-like biologic carriage in the animal branch and has been appropriate in adjustment of tubule action via adjustment of phosphate cotransport . In accession PDZK1 is appropriate for HDL/SR-BI signaling in endothelium and is complex in the aliment of endothelial monolayer integrity.
Overexpression of PDZK1 has been begin in several tumors of epithelial agent and estrogen receptor absolute breast blight and is acceptable to be associated with drug-resistance phenotype in assorted myeloma.
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