PTPRT belongs calm with PTPμ, PTPκ and PCP-2 to the receptor blazon IIb (2B) subfamily of PTPases. The feature protein contains a ample extracellular arena absolute a meprin-A5 antigen-PTP (MAM) area and Ig-like and fibronectin blazon III-like repeats, a individual transmembrane arena and two intracellular catalytic domains.
PTPRT is mutated in several blight types in accurate in colon cancer. Five missense mutations accept been detected in blight tissues abbreviation phosphatase action suggesting a bump suppressor action for this phosphatase. PTPRT has aswell been begin to be upregulated in ERalpha absolute breast cancer.
PTPRT interacts with the catalytically abeyant phosphatase PTPRN, Islet antigen-2 (IA-2), a above autoantigen in blazon 1 diabetes as able-bodied as with several adherens junctional proteins including E-cadherin, p120ctn, N-cadherin, VE-cadherin, desmoglein, α, β and γ catenin as able-bodied as α-actinin.
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From: Proteases Enzyme
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