Folinic acid (INN) or leucovorin (USAN), generally administered as calcium folinate (or leucovorin calcium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is also known as 5-formyl tetrahydrofolate, is one active form in a group of vitamins known as folates. In contrast to folic acid, a synthetic form of folate, folinic acid is one This fact sheet has information about leucovorin while they are brought about with the chemotherapy drugs fluorouracil (5FU) or methotrexate. Folinic acid should be distinguished from folic acid. It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.
Leucovorin is not a chemotherapy drug, but it's often apt every bit component of chemotherapy treatment - either to make the chemotherapy more effective or to decoct the risk of infection of side effects. Leucovorin may also be given with the chemotherapy drug tegafur-uracil (Uftoral®), which is similar to 5FU.
Folinic Acid is a reduced folic acid. Folinic Acid is used in combination with other chemotherapy drugs to either enhance effectiveness, or as a "chemoprotectant."
Leucovorin is often given with 5FU chemotherapy to treat cancers of the colon, rectum and other parts of the digestive system. Adding leucovorin has been shown to increase the effectiveness of the 5FU.
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