Methylcobalamin is a cobalamin (MeB12) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B12. This vitamer is one of two active coenzymes used by B-12 dependent enzymes in the body, and is specifically the B-12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase.
The rationale is that methylcobalamin may help to remove brain-damaging levels of the neurotransmitter glutamate. Methylcobalamin has been reported to have been used to reduce neurotoxicity and lower excess glutamate levels, resulting in the reduction of fatigue, stabilisation of mood, improvement of memory, and executive function. However.
Methylcobalamin has been contemplated in concurrence with sleep-wake regular recurrence disquiets, where it appears to yield benefits, but at a low or inconsistent level. It is used in treating diseases of vitamin B12 deficiency (such every bit insidious anaemia), or diseases of good B12 deficiency, such as vitamin B12 metabolic pathway pathologies.
Unitary canvas suggests that once absorbed, methylcobalamin may be retained in the body better than cyanocobalamin. The liver converts a small amount of cyanocobalamin into methylcobalamin within the body, but larger amounts of methylcobalamin are necessary to correct neurological defects and protect against aging. The most common form of vitamin B12 is called cyanocobalamin.
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