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Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to man.
Function
Yeast Coronin Crn1 and Drosophila Dpod1 were found crosslink actin and microtubule cytoskeleton. C.elegans POD-1 and Drosophila Coronin homologue regulate actin cytoskeleton and are involved in vesicular trafficking.
Seven different isoforms of Coronin have been reported in mammals. The most well studied isoforms are Coronin 1 (Coronin 1A) and Coronin 1B. Coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism.
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