PWhat is IP2 (Phosphatidylinositol-4,5-bisphosphate) Monoclonal Antibody?

PIP2 (Phosphatidylinositol-4,5-bisphosphate) Monoclonal Antibody
Specification:100 µg
Purification:Protein G Affinity
Immunogen:PIP2 from bovine spinal cord
species: Species Independent
Applications: ELISA, Immunocytochemistry
Description of PIP2 (Phosphatidylinositol-4,5-bisphosphate) Monoclonal Antibody
Metabolism of inositol phospholipids by intracellular signaling mediators is fundamental to signal transduction in eukaryotic cells. PI-4,5-P2 (PIP2) can be synthesized by phosphorylation of PI-4-P by type I phosphatidylinositol phosphate kinase (PIP5K I), or phosphorylation of PI-5-P by type II PIPK (PIP4K II). PI-4,5-P2 regulation of cellular calcium levels involves its hydrolysis by Phospholipase C (PLC) to produce inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), which serve as second messengers in the import of calcium via IP3-sensitive ion channels and in the activation of PKC, respectively.
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