What is Tocopherol?

Tocopherols (or TCP) are a chic of actinic compounds of which abounding accept vitamin E activity. It is a alternation of amoebic compounds consisting of assorted methylated phenols. Because the vitamin action was aboriginal articular in 1936 from a comestible abundance agency in rats, it was accustomed the name "tocopherol" from the Greek words acceptation in sum "to backpack a pregnancy," with the catastrophe "-ol" blame its cachet as a actinic alcohol.
alpha-Tocopherol is the capital antecedent begin in supplements and in the European diet, area the capital comestible sources are olive and sunflower oils, while gamma-tocopherol is the a lot of accepted anatomy in the American diet due to a college assimilation of soybean and blah oil.,
Tocotrienols, which are accompanying compounds, aswell accept vitamin E activity. All of these assorted derivatives with vitamin action may accurately be referred to as "vitamin E." Tocopherols and tocotrienols are fat-soluble antioxidants but aswell assume to accept abounding added functions in the body.
Tocopherols, although beneath frequently known, aswell accord to the vitamin E family. Tocotrienols accept four accustomed 2' d-isomers (they accept a stereoisomeric carbon alone at the 2' ring-tail position). The four tocotrienols (in adjustment of abbreviating methylation: d-alpha, d-beta, d-gamma, and d-delta-tocotrienol) accept structures agnate to the four tocopherols, except with an unsaturated band in anniversary of the three isoprene units that anatomy the hydrocarbon tail, admitting tocopherols accept a saturated phytyl appendage (the phytyl appendage of tocopherols gives the achievability for 2 added stereoisomeric sites in these molecules that tocotrienols do not have). Tocotrienol has been accountable to beneath analytic studies and apparent beneath analysis as compared to tocopherol. However, there is growing absorption in the bloom furnishings of these compounds.
Alpha-tocopherol is the form of vitamin E that is preferentially absorbed and accumulated in humans. The measurement of "vitamin E" activity in international units (IU) was based on fertility enhancement by the prevention of miscarriages in pregnant rats relative to alpha-tocopherol.
Although the mono-methylated form ddd-gamma-tocopherol is the most prevalent form of vitamin E in oils, there is evidence that rats can methylate this form to the preferred alpha-tocopherol, since several generations of rats retained alpha-tocopherol tissue levels, even when fed only gamma-tocopherol through their lives.
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Uses of Phosphomannomutase PMM2 Monoclonal Antibody 2E9

Phosphomannomutase PMM2 Monoclonal Antibody 2E9 encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a forerunner to GDP-mannose all-important for the amalgam of dolichol-P-oligosaccharides. Mutations in this gene accept been apparent to could cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein affection blazon I.
In enzymology, a phosphomannomutase (EC 5.4.2.8) is an agitator that catalyzes the actinic reaction
alpha-D-mannose 1-phosphate rightleftharpoons D-mannose 6-phosphate
Hence, this agitator has one substrate, alpha-D-mannose 1-phosphate, and one product, D-mannose 6-phosphate.
This agitator belongs to the ancestors of isomerases, accurately the phosphotransferases (phosphomutases), which alteration phosphate groups aural a molecule. The analytical name of this agitator chic is alpha-D-mannose 1,6-phosphomutase. Other names in accepted use cover mannose phosphomutase, phosphomannose mutase, and D-mannose 1,6-phosphomutase. This agitator participates in fructose and mannose metabolism. It has 2 cofactors: D-glucose 1,6-bisphosphate, and D-Mannose 1,6-bisphosphate.
Uses of Phosphomannomutase PMM2 Monoclonal Antibody 2E9
Antibody reactive against transfected lysate and recombinant protein for Western Blot. Has also been used for ELISA.
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What is the health benefits of Phylloquinone?

Phylloquinone is a polycyclic ambrosial ketone, based on 2-methyl-1,4-naphthoquinone, with a 3-phytyl substituent.It is a fat-soluble vitamin that is abiding to air and damp but decomposes in sunlight. It is begin by itself in a advanced array of blooming plants.
It is generally alleged vitamin K1, phytomenadione or phytonadione. Sometimes a acumen is fabricated with phylloquinone advised accustomed and phytonadione advised synthetic.A stereoisomer of phylloquinone is alleged vitamin k1 (note the aberration in capitalization).
Phylloquinone is an electron acceptor during photosynthesis, basic allotment of the electron carriage alternation of Photosystem I.Its best-known action in animals is as a cofactor in the accumulation of agglomeration factors II (prothrombin), VII, IX, and X by the liver. It is aswell appropriate for the accumulation of anticoagulant factors protein C and S. It is frequently acclimated to amusement warfarin toxicity, and as an antitoxin for coumatetralyl.Vitamin K is aswell appropriate for cartilage protein formation.
Phylloquinone or vitamin K is a fat soluble vitamin that comes in two forms: menaquinone and phylloquinone. Vitamin K1 is called as hylloquinone, found in plants whereas vitamin K2 is called as menaquinone occurred due to synthesizing by many friendly bacteria.
Health Benefits of Phylloquinone
Phylloquinone is complex in claret agglomeration and is benign to synthesise alarmist protein. It is acclimated in the accumulation of important prothrombin or the forerunner to thrombin – plays a abundant role in claret clotting. Phylloquinone aswell deals with cartilage acclimation and formation. In the intestines, Phylloquinone helps to catechumen glucose to glycogen and after abundance in the liver. As per assorted researches, Vitamin K helps to abate the severity of osteoporosis and lowers the cartilage loss. Early medical analysis appropriate that low Phylloquinone cachet is assembly with low cartilage accumulation and top accident agency in aged patients. Assorted analysis works has began to advance the cartilage mineral density. In some patients, Vitamin K decreases the accident agency of cartilage breach and focus on acceptable cartilage health. Other than that, Phylloquinone helps to accomplish accustomed alarmist functioning, affection animation and longevity, reduces morning sickness, and works admiration on cystic fibrosis and Chrohn’s disease.
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What is Protein Phosphatase PPEF1 Monoclonal Antibody 1F6-1A5?

Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene.
PPEF-1 is a Ser/Thr phosphatase. Contains at least two EF-hand calcium-binding motifs in its C terminus. May play a role in specific sensory neuron function and/or development. Shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.
PPEF1 has been shown to interact with Calmodulin 1
PPEF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535~564 amino acids from the C-terminal region of human PPEF1.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPEF1
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What is Casein phosphopeptides(CPP)?

A Casein phosphopeptides composition is prepared containing less than 4% phenylalanine, tyrosine and tryptophan, greater than 8% and less than 20% serine, a ratio of Ca+Mg+P/NT greater than 0.2, wherein NT is the total nitrogen content times 6.38, and free amino acids of less than 3%. The composition is useful as an ailment for dietetic or therapeutic nutrition or as a medicament. Salts of the phosphopeptides may be formed from macroelements such as calcium and/or magnesium and/or from oligoelements such as iron, zinc and copper. The composition is produced by proteolytic enzyme hydrolysis of a casein-based material, and using ultrafiltration and aggregration with a bivalent cation salt to isolate the phosphopeptide composition.
Recaldent, with the technical name Casein phosphopeptides – amorphous calcium phosphate, or CPP-ACP, is a milk-derived product that strengthens and remineralizes teeth and helps prevent dental caries (tooth decay). Casein phosphopeptides (CPP) from the major protein of milk have the ability to stabilize calcium, phosphate and fluoride ions as water soluble amorphous complexes that provide bioavailable calcium, phosphate and fluoride ions to the tooth. These complexes of amorphous calcium phosphate and amorphous calcium fluoride phosphate stabilized by the CPP have been demonstrated in a range of laboratory, animal and short-term human clinical trials to repair (remineralise) early stages of tooth decay by replacing the calcium and phosphate ions lost due to decay. Three longer-term, randomized, controlled clinical trials (RCTs) have demonstrated the efficacy of CPP-ACP in slowing the progression of dental caries and in regressing (repairing) early stages of tooth decay. Another RCT showed that CPP and calcium carbonate in a toothpaste formulation, which would spontaneously form CPP-ACP in saliva, significantly reduced caries experience in children compared with a placebo toothpaste. A systematic review with meta-analysis by Yengopal and Mickenautsch concluded that “the results of the clinical in situ trials indicate a short-term remineralization effect of CPP-ACP. Additionally, the promising in vivo RCT results suggest a caries-preventing effect for long-term clinical CPP-ACP use”. Recaldent (CPP-ACP) can be delivered to the teeth by sugar-free gum (Trident XtraCare with Recaldent), professional tooth crème (GC's Tooth Mousse, MI Paste and MI Paste Plus) and dairy milk (Meiji Milk de Recaldent).
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What is GSK-3 alpha/beta (phospho-Tyr216/Tyr279) Monoclonal Antibody (6D3)?

Specificity
GSK-3 alpha/beta (phospho-Tyr216/Tyr279) Monoclonal Antibody detects endogenous levels of GSK-3 only when phosphorylated at serine 21 of GSK-3alpha or serine 9 of GSK-3beta.
Source
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to the sequence of human GSK-3 alpha. Antibodies are purified by protein A and peptide affinity chromatography.
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization .
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Where to get Triosephosphate isomerase TPI1 Monoclonal Antibody 1D10-2E2?

Triosephosphate isomerase TPI1 Monoclonal Antibody 1D10-2E2
Immunogen TPI1 (AAH07086.1, 1 a.a. ~ 249 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Mouse monoclonal antibody raised against a full length recombinant TPI1.
Uses
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.
Storage:Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
Triosephosphate isomerase (TIM) catalyses the reversible interconversion of G3P and DHAP. Only G3P can be used in glycolysis, therefore TIM is essential for energy production, allowing two molecules of G3P to be produced for every glucose molecule, thereby doubling the energy yield. Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
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What is PI3-kinase p85 alpha phospho-Tyr368 PIK3R1 Polyclonal Antibody?

PI3-kinase p85 alpha phospho-Tyr368 PIK3R1 Polyclonal Antibody
Applications:Dot-Pep, ELISA
Immunogen:Rabbit polyclonal antibody raised against synthetic phosphopeptides of PIK3R1.
Description:
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The agitator comprises a 110 kD catalytic subunit and a authoritative subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD authoritative subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic accomplishments of insulin, and a alteration in this gene has been associated with insulin resistance. Alternative splicing of this gene after-effects in three archetype variants encoding altered isoforms.
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Uses of Calcium pyruvate

Calcium pyruvate is a nutritional supplement that combines naturally occurring pyruvic acid with calcium. While pyruvate is produced in the body and aids in the conversion of sugar and starches into energy, calcium pyruvate can help enhance the metabolism and speed up the creation of energy. Along with helping people feel more energized, using the supplement can also aid in weight loss when used in conjunction with a sensible diet and regular exercise.
Because calcium pyruvate helps in burning fat to create more fuel for the body to use, the supplement helps to reduce fat that is retained in the body. Thus, the supplement can minimize the amount of excess fat that is stored around the abdomen and other parts of the body. The additional energy that is generated helps the body to function more efficiently and comes in handy when exercising as part of an overall health improvement regimen. In an indirect manner, this also means that calcium pyruvate aids in mental as well as physical health, since emotional issues often have a physical origin.
Uses of Calcium pyruvate
Aging skin. Applying a 50% pyruvic acid skin peel once a week for 4 weeks seems to smooth skin, decrease fine wrinkles, and decrease dark spots associated with aging due to sun exposure.
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What is Cholecalciferol?

Cholecalciferol is a form of vitamin D, also called vitamin D3 or calcitriol.
It is structurally similar to steroids such as testosterone, cholesterol, and cortisol (though vitamin D3 itself is a secosteroid).
Forms
Vitamin D3 has several forms:
Cholecalciferol, (sometimes called calciol) is an inactive, unhydroxylated form of vitamin D3)
Calcifediol (also called calcidiol, hydroxycholecalciferol, 25-hydroxyvitamin D3, etc. and abbreviated 25(OH)D is one of the forms measured in the blood to assess vitamin D status
Calcitriol (also called 1,25-dihydroxyvitamin D3) is the active form of D3.
Cholecalciferol is synthesized in the skin from 7-dehydrocholesterol under the action of ultraviolet B light. It reaches an equilibrium after several minutes depending on several factors including conditions of sunlight (latitude, season, cloud cover, altitude), age of skin, and color of skin.
Although Cholecalciferol can be synthesized in the skin (see Metabolism), it is also a form of vitamin D added to fortify foods. Cholecalciferol is produced industrially by the irradiation of 7-dehydrocholesterol extracted from lanolin found in sheep's wool. In foods where animal products are not desired, an alternative compound is ergocalciferol (also known as vitamin D2) derived from the fungal sterol ergosterol.
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Are you looking for Protein Phosphatase, beta PPP3R2 Monoclonal Antibody 5D9?

Protein phosphatases are a group of enzymes, found ubiquitously, which are responsible for the dephosphorylation of various proteins and enzymes in a cell. This role is an extremely important one since protein phosphorylation and dephosphorylation is required for the regulation of a large number of cellular activities.
Protein phosphatases were first reported to be inhibited by microcystins by Mackintosh et. al. (1990). It was found that extremely low concentrations of microcystin-LR could strongly inhibit protein phosphatases 1 and 2A from both plants and mammals, thereby causing hyperphosphorylation of the cell and a massive disruption of a number of important cellular mechanisms.
The binding of microcystins to protein phosphatases is covalent and therefore very inhibitory and highly specific. The processes involved in the binding of microcystins to protein phosphatases is the subject of some research.
Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene.
Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase, is a ubiquitous and conserved Serine/Threonine phosphatase with broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT.
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How to get Ganodenic Acid?

Ganodenic Acid is a chic of carefully accompanying triterpenoids (derivatives from lanosterol) begin in Ganoderma mushrooms.
There are dozens of Ganodenic acids that accept been abandoned and characterized, of which ganoderic acerbic A and ganoderic acerbic B are the a lot of able-bodied characterized. Some ganoderic acids accept been begin to acquire biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition.
Ganodenic acerbic aswell has able medical action on acesodyne, sedation, detoxification.
Ganodenic Acid is a kind of triterpene. More than 100 kinds have been isolated from the Ganoderma Lucidum. It has strong medical function on acesodyne,  sedation, detoxification, protecting the liver, killing tumor cell, etc.
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What is Ergocalciferol?

Ergocalciferol is a form of vitamin D, also called vitamin D2. It is marketed under various names including Deltalin (Eli Lilly and Company), Drisdol (Sanofi-Synthelabo) and Calcidol (Patrin Pharma). Created from viosterol when ultraviolet light activates ergosterol (found in fungi, it is named as a sterol from ergot), with fungi as the primary plant source.
Ergocalciferol may be used as a vitamin D supplement, and a 2011 clinical guideline considered it to be as effective as cholecalciferol (vitamin D3), which is produced naturally by the skin when exposed to ultraviolet light. Conflicting evidence exists for how similarly D2 and D3 behave in the body and whether they are equally active, with some studies suggesting D3 is more potent, while others report equal efficacy. Cholecalciferol (vitamin D3) is sensitive to UV radiation and rapidly, but reversibly, forms other sterols which can further irreversibly convert to ergosterol.
Ergocalciferol is produced in fungus synthetically from radiating an ergosterol. Human bioavailability of vitamin D2 from vitamin D2-enhanced button mushrooms via UV-B irradiation is effective in improving vitamin D status and not different to a vitamin D2 supplement. Vitamin D2 from UV-irradiated yeast baked into bread is bioavailable. By visual assessment or using a chromometer, no significant discoloration of irradiated mushrooms, as measured by the degree of "whiteness", was observed. Claims have been made that a normal serving (approx. 3 oz or 1/2 cup, or 60 grams) of mushrooms treated with ultraviolet light provides vitamin D content to levels of 3,476 IU if exposed to just 5 minutes of UV light after being harvested.
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Precautions of Phospho-Ser/Thr/Tyr Monoclonal Antibody (SPM101)

Phospho-Ser/Thr/Tyr Monoclonal Antibody (SPM101)
INTENDED USE: For Research Use Only.  Not for use in diagnostic procedures. 
CLONE: SPM101
IMMUNOGEN: Phosphoserine, phosphothreonine, and phosphotyrosine conjugated to protein carriers.   
IG ISOTYPE: IgG1
DESCRIPTION: This antibody recognizes serine, threonine, and tyrosine phosphorylated proteins as determined
by ELISA using phosphorylated peptides. Reactivity has also been shown with phosphorylated
proteins in western blots.
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Kinase Assay, Western blot
WARNINGS & PRECAUTIONS of Phospho-Ser/Thr/Tyr Monoclonal Antibody (SPM101)
1.Avoid contact of reagents with eyes and mucous membranes.  If reagents come into
contact with sensitive areas, wash with copious amounts of water.
2.This product is harmful if swallowed. 
3.This product contains sodium azide, a chemical highly toxic in pure form.
concentrations, though not classified as hazardous, sodium azide may react with lead and
copper plumbing.  Upon disposal, flush with large volumes of water to prevent metal azide
buildup in plumbing. 
4.Consult local or state authorities with regard to recommended method of disposal.  In the
European Union, this material and its container must be disposed of as hazardous waste.
5.Avoid microbial contamination of reagents.
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What is GSK-3 alpha/beta (phospho-Tyr216/Tyr279) Polyclonal Antibody?

GSK-3 alpha/beta (phospho-Tyr216/Tyr279) Polyclonal Antibody
Applications Dot, ELISA, WB
Species Human
Reactivity Human, Mouse, Rat.
Specificity
Phosphorylation site-specific antibody selective for the phosphorylated isoforms of glycogen synthase kinase enzyme, GSK 3 alpha, a 51 kDa protein containing a phosphate on tyrosine 279, and GSK 3 beta, a 47 kDa protein containing a phosphate on tyrosine 216.
Immunogen
Synthetic peptide derived from the regions of GSK 3 alpha + beta protein that contain tyrosine 216/279.
Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, alpha and beta, and they show a high degree of amino acid homology. The two isoforms of GSK3 are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor 1 (HSF1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer's disease. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.
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What is FAK (phospho-Tyr397) Polyclonal Antibody?

FAK (phospho-Tyr397) Polyclonal Antibody
Applications Immunoblotting and Immunostaining
Species Request Info
Reactivity Human, Mouse, Chicken, Frog, Drosophila
Description
phospho-Tyr397 Polyclonal Antibody to FAK, phospho tyrosine 397
Affinity Purified Antibody (Stored in PBS [w/o Mg2+ or Ca2+], pH 7.3, with 1.0 mg/mL BSA [IgG and protease free] as a carrier), Contains 0.05% sodium azide
Focal Adhesion Kinase (FAK) is a 125 kD non-receptor protein tyrosine kinase that was discovered as a substrate for Src, and is a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK. The site binds Src family SH2 domains and the p85 subunit of PI3-Kinase.
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of FAK that contains tyrosine 397. The sequence is conserved in human, mouse, rat, chicken and frog.
The antibody has been purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated FAK. The final product is generated by affinity chromatography using a FAK-derived peptide that is phosphorylated at tyrosine 397.
The antibody is effective in immunoblotting and immunostaining.
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What is v-Akt phospho-Ser124 AKT1 Polyclonal Antibody?

Descriptions of v-Akt phospho-Ser124 AKT1 Polyclonal Antibody
Molecule Descriptor    
Synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of serine 124 (SGSPPS)
Applications ELISA, IHC-P, WB
Species Human
Reactivity Human, Mouse, Rat.
Molecule Synonym    
RAC, vAKT Murine Thymoma Viral Oncogene Homolog 1, PRKBA, C AKT, PKB, RAC Serine/Threonine Protein Kinase, Oncogene AKT1, MGC9965, RAC PK Alpha, RAC Alpha, Protein Kinase B Alpha, AKT 1, RAC alpha serine/threonine protein kinase, cAKT, MGC99656, PKB-ALPHA, Protein kinase B, RAC-PK-alpha, Proto-oncogene c-Akt, AKT1, AKT1_HUMAN, RAC-alpha serine/threonine-protein kinase
v-Akt phospho-Ser124 AKT1 Polyclonal Antibody is serine-threonine protein kinase encoded by the AKT1 gene is catalytically abeyant in serum-starved primary and immortalized fibroblasts. AKT1 and the accompanying AKT2 are activated by platelet-derived advance factor. The activation is accelerated and specific, and it is abrogated by mutations in the pleckstrin affinity area of AKT1. It was apparent that the activation occurs through phosphatidylinositol 3-kinase. In the developing afraid arrangement AKT is a analytical advocate of advance factor-induced neuronal survival. Adaptation factors can abolish apoptosis in a transcription-independent address by activating the serine/threonine kinase AKT1, which again phosphorylates and inactivates apparatus of the apoptotic machinery. Multiple alternatively spliced archetype variants accept been begin for this gene.
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Applications of Sodium gluconate

Molecular Formula: C6H11NaO7
CAS No.: 527-07-1
Molar mass:  218.13847
Sodium Gluconate F.C.C. is a high quality crystalline sodium salt of gluconic acid. It appears as white crystals that exhibit excellent solubility. This non-corrosive, non-toxic and highly pure gluconate is an excellent choice when dry material is preferred. Bulk density is approximately 59 pounds per cubic foot (0.95 g/cc).
Sodium gluconate is a compound with formula NaC6H11O7. It is the sodium salt of gluconic acid. It has E number E576.
Applications of Sodium gluconate
Biodegradable chelating agent (Sequestrant); steel, glass bottle cleaner; pipe-line anti-scale additive (food and pharm industry); cement additive.
Specifications:
Sodium Gluconate is available in granular and powder form. Sodium Gluconate complies with the requirements of the Food Chemicals Codex.
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What is GFAP (phospho-Ser8) Monoclonal Antibody (YC10)?

GFAP (phospho-Ser8) Monoclonal Antibody (YC10)
Specification:50 µg 
Purification:Protein A Affinity
Immunogen:Synthetic phospho-peptide derived from the sequence of pig GFAP, conjugated to KLH
Storage pH: 7.20
Constituents: 49% PBS, 50% Glycerol
Description of GFAP (phospho-Ser8) Monoclonal Antibody (YC10)
Glial Fibrillary Acidic Protein (GFAP) is an intermediate-filament (IF) protein that is specific for cells of astroglial lineage. The major IF protein expressed in precurosor astrocytes in the CNS is usually vimentin. A switch between vimentin and GFAP expression occurs following astrocyte maturation, making GFAP a widely used marker for astrocyte maturation. GFAP expression is modulated by several hormones including thyroid hormone, glucocorticoids and several growth factors such as FGF, CNTF, and TGF-beta.
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What is Calcium D-pantothenate?

Calcium D-pantothenate, aswell referred to as vitamin B-5 or pantothenic acid, is an capital comestible your physique uses to accomplish activity by breaking down carbohydrates and fats. Adults should absorb at atomic 5 mg of calcium D-pantothenate anniversary day to advance a advantageous body, according to the University of Maryland Medical Center. If you accept agitation accepting abundant of this B-5 vitamin from your diet, your doctor may acclaim analysis with a calcium D-pantothenate supplement. Before you activate demography this supplement, be abiding to allocution with a doctor about calcium D-pantothenate ancillary effects.
Nausea and Heartburn
After taking a dose of this supplement, you may experience stomach irritation. Nausea may be uncomfortable and may contribute to a temporary loss of appetite. You may also develop heartburn, the Linus Pauling Institute at Oregon State University reports. This side effect may result in the development of a burning sensation in the center of your chest or along the top of your stomach. If stomach-related side effects persist or become severe while you are taking Calcium D-pantothenate, seek additional care from your doctor.
Pantothenic acid is essential to all life, and is a component of coenzyme A (CoA), a molecule that is necessary for numerous vital chemical reactions to occur in cells. Pantothenic acid is essential to the metabolism of carbohydrates, proteins, and fats, as well as for the synthesis of hormones and cholesterol.
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What is Protein Phosphatase, beta PPP3R2 Monoclonal Antibody 5D9?

Specification:100 µg 
Applications:
Antibody reactive against transfected lysate and recombinant protein for western blot. It has also been used for ELISA.
Immunogen:Mouse monoclonal antibody raised against a partial recombinant PPP3R2.
Description of Protein Phosphatase, beta PPP3R2 Monoclonal Antibody 5D9
Species Reactivity:H
Isotype :IgG2a kappa
Clone :5D9
Host:Mouse
Specificity: PPP3R2 - protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II)
Protein Phosphatase, beta PPP3R2 Monoclonal Antibody 5D9 is produced by and distributed for Abnova, a company based in Taiwan.
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Where to get GFAP (phospho-Ser8) Monoclonal Antibody (YC10)?

Description of GFAP (phospho-Ser8) Monoclonal Antibody (YC10)
Purification:Protein A Affinity
Immunogen:Synthetic phospho-peptide acquired from the arrangement of pig GFAP, conjugated to KLH
GFAP(Glial Fibrillary Acidic Protein) is an intermediate-filament (IF) protein that is specific for beef of astroglial lineage. The above IF protein bidding in precurosor astrocytes in the CNS is usually vimentin. A about-face amid vimentin and GFAP announcement occurs afterward astrocyte maturation, authoritative GFAP a broadly acclimated brand for astrocyte maturation. GFAP announcement is articulate by several hormones including thyroid hormone, glucocorticoids and several advance factors such as FGF, CNTF, and TGF-beta.
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Where to get HSF1 (phospho-Ser326) Polyclonal Antibody?

Immunogen:Synthetic phospho-peptide acquired from the N-terminus of Human HSF1
Description of HSF1 (phospho-Ser326) Polyclonal Antibody
HSFs (Heat Shock ancestors of archetype factors), which consists of HSF 1-4, bind to awful conserved Calefaction shock elements (HSEs) in the apostle regions of calefaction shock genes, ultimately acclimation the announcement of Calefaction shock proteins (Hsps). On acknowledgment to calefaction shock and added stresses, HSF1 localizes aural abnormal to detached nuclear granules and on accretion from stress, HSF1 rapidly dissipates from the accent granules to a broadcast nucleoplasmic distribution.
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Properties of Histidine

Histidine (abbreviated as His or H) Histidine, an capital amino acid, has a absolutely answerable imidazole anatomic group. It is one of the 22 proteinogenic amino acids. Its codons are CAU and CAC. Histidine was aboriginal abandoned by German physician Albrecht Kossel in 1896. Histidine is an capital amino acerbic in bodies and added mammals. It was initially anticipation that it was alone capital for infants, but longer-term studies accustomed that it is aswell capital for developed humans.
Properties
The imidazole sidechain of histidine has a pKa of about 6.0, and, overall, the amino acerbic has a pKa of 6.5. This agency that, at physiologically accordant pH values, almost baby accouterment in pH will change its boilerplate charge. Below a pH of 6, the imidazole ring is mostly protonated as declared by the Henderson–Hasselbalch equation. When protonated, the imidazole ring bears two NH bonds and has a absolute charge. The absolute allegation is appropriately broadcast amid both nitrogens and can be represented with two appropriately important resonance structures.
Aromaticity
The imidazole ring of histidine is ambrosial at all pH values. It contains six pi electrons: four from two bifold bonds and two from a nitrogen abandoned pair. It can anatomy pi stacking interactions, but is complicated by the absolute charge. It does not blot at 280 nm in either state, but does in the lower UV ambit added than some amino acids.
Biochemistry
The imidazole sidechain of Histidine is a accepted analogous ligand in metalloproteins and is a allotment of catalytic sites in assertive enzymes. In catalytic triads, the basal nitrogen of histidine is acclimated to abstruse a proton from serine, threonine, or cysteine to actuate it as a nucleophile. In a histidine proton shuttle, histidine is acclimated to bound shuttle protons, it can do this by abstracting a proton with its basal nitrogen to accomplish a positively-charged average and again use addition molecule, a buffer, to abstract the proton from its acerb nitrogen. In carbonic anhydrases, a histidine proton shuttle is activated to rapidly shuttle protons abroad from a zinc-bound baptize atom to bound change the alive anatomy of the enzyme.
As expected, the 15N actinic accouterment of these nitrogens are duplicate (about 200 ppm, about to nitric acerbic on the sigma scale, on which added careful corresponds to added actinic shift). As the pH increases to about 8, the protonation of the imidazole ring is lost. The actual proton of the now-neutral imidazole can abide on either nitrogen, giving acceleration to what is accepted as the N-1 or N-3 tautomers. NMR shows that the actinic about-face of N-1 drops slightly, admitting the actinic about-face of N-3 drops appreciably (about 190 vs. 145 ppm). This indicates that the N-1-H tautomer is preferred, it is accepted due to hydrogen bonding to the adjoining ammonium. The careful at N-3 is essentially bargain due to the second-order paramagnetic effect, which involves a symmetry-allowed alternation amid the nitrogen abandoned brace and the aflame pi* states of the ambrosial ring. As the pH rises aloft 9, the actinic accouterment of N-1 and N-3 become about 185 and 170 ppm. It is account acquainted that the deprotonated anatomy of imidazole, imidazolate ion, would be formed alone aloft a pH of 14, and is accordingly not physiologically relevant. This change in actinic accouterment can be explained by the apparently decreased hydrogen bonding of an amine over an ammonium ion, and the favorable hydrogen bonding amid a carboxylate and an NH. This should act to abatement the N-1-H tautomer preference.
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Uses of Zinc Gluconate

Zinc Gluconate (also called zincum gluconicum) is the zinc salt of gluconic acid. It is an ionic compound consisting of two moles of gluconate for each mole of zinc. Zinc gluconate is a popular form for the delivery of zinc as a dietary supplement.
Gluconic acid is found naturally, and is industrially manufactured by the fermentation of glucose, typically by Aspergillus niger, but also by other fungi, e.g. Penicillium, or by bacteria, e.g. Acetobacter, Pseudomonas and Gluconobacter. In its pure form, it is a white to off-white powder. It can also be manufactured by electrolytic oxidation, although this is a more expensive process. The advantages are a lower microbiological profile, and a more complete reaction, yielding a product with a longer shelf life.
Zinc gluconate may interfere with the absorption of antibiotics, so combinations may be unsafe.
Zinc Gluconate contains not less than 97.0 percent and not more than 102.0 percent of C12H22O14Zn, calculated on the anhydrous basis.
Characteristic: Dehydrate compound, white or off-white crystal powder, be soluble easily in water, no odor and taste, hardly soluble in ethanol, chloroform and aether
Usage And Functions
An essential element for normal growth and good vision. Its benefit in maintaining healthy skin, bones, collagen and protein synthesis as well as proper sexual function and the immune system; help in the utilisation of vitamin A, Calcium and Phosphorous. A Zinc supplement may help to ensure against any deficit in the diet, especially during the winter months.
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Where to get GSK-3 alpha/beta (phospho-Tyr216/Tyr279) Polyclonal Antibody?

Immunogen
Synthetic peptide (Human) (C terminal).
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Primary antibody notes
GSK-3 (Glycogen Synthase Kinase-3 differs from most serine/threonine kinases) in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK-3a and GSK-3ß. The function of GSK-3 is to phosphorylate glycogen synthase and thereby inactivate it. Insulin action stimulates the PI 3-kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK-3.
Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, alpha and beta, and they show a high degree of amino acid homology. The two isoforms of GSK3 are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor 1 (HSF1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer's disease. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.
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Descriptions of Tau phospho-Ser720 MAPT Polyclonal Antibody

Tau phospho-Ser720 MAPT Polyclonal Antibody
Specification:100 µg
Applications:Dot-Pep, ELISA
Immunogne:Rabbit polyclonal antibody raised against synthetic phosphopeptides of MAPT.
Description of Tau phospho-Ser720 MAPT Polyclonal Antibody
Tau phospho-Ser720 MAPT Polyclonal Antibody encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
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