Molecule Descriptor
Synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of serine 124 (SGSPPS)
Applications ELISA, IHC-P, WB
Species Human
Reactivity Human, Mouse, Rat.
Molecule Synonym
RAC, vAKT Murine Thymoma Viral Oncogene Homolog 1, PRKBA, C AKT, PKB, RAC Serine/Threonine Protein Kinase, Oncogene AKT1, MGC9965, RAC PK Alpha, RAC Alpha, Protein Kinase B Alpha, AKT 1, RAC alpha serine/threonine protein kinase, cAKT, MGC99656, PKB-ALPHA, Protein kinase B, RAC-PK-alpha, Proto-oncogene c-Akt, AKT1, AKT1_HUMAN, RAC-alpha serine/threonine-protein kinase
v-Akt phospho-Ser124 AKT1 Polyclonal Antibody is serine-threonine protein kinase encoded by the AKT1 gene is catalytically abeyant in serum-starved primary and immortalized fibroblasts. AKT1 and the accompanying AKT2 are activated by platelet-derived advance factor. The activation is accelerated and specific, and it is abrogated by mutations in the pleckstrin affinity area of AKT1. It was apparent that the activation occurs through phosphatidylinositol 3-kinase. In the developing afraid arrangement AKT is a analytical advocate of advance factor-induced neuronal survival. Adaptation factors can abolish apoptosis in a transcription-independent address by activating the serine/threonine kinase AKT1, which again phosphorylates and inactivates apparatus of the apoptotic machinery. Multiple alternatively spliced archetype variants accept been begin for this gene.
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