Immunogen TPI1 (AAH07086.1, 1 a.a. ~ 249 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Mouse monoclonal antibody raised against a full length recombinant TPI1.
Uses
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.
Storage:Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
Triosephosphate isomerase (TIM) catalyses the reversible interconversion of G3P and DHAP. Only G3P can be used in glycolysis, therefore TIM is essential for energy production, allowing two molecules of G3P to be produced for every glucose molecule, thereby doubling the energy yield. Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
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Isomers present in many varieties can generally be divided into structural isomers and stereoisomers. Structural isomers have a different sequence and/or different connectivity of bonds from one another. isomerase introduction
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